头条推荐

广安理工学院筹建处2024年诚聘海内外高层次人才公告

江苏理工学院2024年人才招聘简章

温州商学院2024年高层次人才招聘公告

扬州工业职业技术学院2024年高层次人才招聘公告

齐鲁医药学院2024年诚聘海内外高层次人才

新疆财经大学2024年高层次人才引进

位置:首页 > 博士后招收 > 海外博士后招聘 >

美国哈佛医学院微生物毒素、细菌感染和宿主微生物相互作用方向博士后

时间:2018-08-08来源:研究生招聘网

Postdoctoral fellow

Two postdoctoral fellow positions are available in Dr. Min Dong’s lab at Harvard Medical School. Potential projects include:

(1) Mechanism of bacterial toxins and effectors: we are studying botulinum neurotoxins, tetanus neurotoxin, Shiga toxin, Clostridium difficile toxins, and many bacterial effectors using latest experimental approaches.

(2) Host-microbe interactions: enteric pathogens (e.g., C. difficile infections) and microbiome; urinary tract infections and urinary microbiome.

(3) Developing novel therapeutic toxins: apply modern protein engineering methods to develop novel therapeutic toxins for treating chronic pain and cancer. These positions will have many opportunities to work closely with our industry partners.

(4) Cell biology of neurons / electrophysiology: the candidate will apply imaging and electrophysiological approaches to characterize a few newly generated knock-out/knock-in mouse lines, focusing on (1) synaptic vesicle exocytosis/recycling; (2) cytoskeleton regulation by ROCO kinases; (3) endosomal sorting and trafficking in cells.

Our laboratory has a broad interest in microbial toxins, bacterial infections, and host-microbe interactions. We are also utilizing toxins as tools to study fundamental cell biology questions on membrane trafficking, Wnt signaling, and cytoskeleton remodeling. Along these lines of basic research, we are keen in developing microbial toxin-inspired novel protein therapeutics for treating cancer, pain, and other neurological disorders. We have a multi-disciplinary team crossing microbiology, protein engineering, cell biology, and neuroscience fields, and are funded by grants from NIH and industry. Recent achievements include identification of receptors for C. difficile toxin via genome-wide CRISPR-Cas9 screen (Nature, 2016, 538:350, Science, 2018, 360:664), identification of novel botulinum neurotoxins (Nature Communications, 2017, 8:14130; Cell Host and Microbe, 2018, 23:169), and protein engineering of botulinum neurotoxins (Nature Communications, 2017, 8:53). Please see lab website for details: http://donglab.hms.harvard.edu.

Interested candidates please forward your curriculum vitae and names of three references to Dr. Min Dong by email: donglab@childrens.harvard.edu

(责任编辑:shenqian)

更多信息,请扫描下方二维码关注博士研究生招聘网官方微信(微信号:job100zp)与官方微博。

官方微信
官方微博
    Top